Principal Scientist, ADME/PKPD in Waltham, MA at APEX Systems

Date Posted: 10/11/2019

Job Snapshot

  • Employee Type:
    Full-Time
  • Location:
    Waltham, MA
  • Job Type:
  • Experience:
    Not Specified
  • Date Posted:
    10/11/2019

Job Description

Job #:  1006355
Senior Scientist/Principal Scientist, ADME & PK/PD, 1006355
Job Scope & Purpose:
Come join a growing Biotech that is pioneering new RNA-targeting small molecule therapies for genetic types of cancer and genetic related neurological disorders?. Our Exclusive client is seeking a strong preclinical expert with GLP study execution of ADME and PK/PD modeling to help them design and execute preclinical studies. As a part of a growing team, you will be relied upon to will contribute to moving projects with cross-functional teams from discovery to IND-enabling studies and clinical stages. You will work independently to contribute to PK/PD, PBPK, dosing studies, and therapeutic index predictions in guiding preclinical decision making. 
 If this sounds like a great step for your career contact the Stratacuity R&D team today to learn more about this exciting research role. 
Primary Role Responsibilities:
  • You will collaborate in this role with other scientists, including Medicinal Chemists, Toxicologists, Pharmacologists, and external Consultants to execute and interpret results from in vitro and in vivo ADME & PK/PD studies.
  • Provide ADME support for optimization of small molecule therapeutics.?
  • You will work Independently develop solutions and strategies and then oversee ADME & PK/PD studies conducted with vendors, and outsource nonclinical studies to appropriate CROs?
  • You will design studies and be relied upon for reporting and interpretation of exploratory and GLP-compliant ADME & PK/PD studies that are outsourced
  • Summarize ADME & PK studies and PBPK modeling results for internal and external review and regulatory submissions
  • May participate in early clinical candidate selection and asset characterization in support of clinical trials
  • Assess innovative technologies in the field of ADME/PK and Physiologically based pharmacokinetic modeling and provide recommendations to advance pipeline programs

Primary Role Requirements: 
  • Ph.D. with 4+ years of industry experience or MS/BS with 10+ years in Safety Pharmacology, Pharmacokinetics, Pharmacodynamics, or ADME disciplines in biotech, pharmaceutical, or CRO experience will be considered
  • Expertise with ADME, PK, and bioanalytical assay and study design. Understanding of therapeutic exposure-effect relationships and physiologically-based pharmacokinetic (PBPK) software modeling is valuable
  • Familiarity with the phases of drug discovery and development, with an emphasis on compound selection and translational research
  • Experience with clinical pharmacology or popPK modeling is a plus, but not a mandatory skill needed
  • Experience with the design and execution of in vivo experiments or dosing studies to determine the effects of small molecule therapeutics related to human safety risk understanding
  • Hands-on experience with in vitro ADME assays, PK/PD, and PBPK modeling and ability to transfer externally is valuable 
  • Ability to adapt to an evolving biotech environment and address needs as they arise 

About Stratacuity:
Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.
PROVEN SCIENTIFIC PLACEMENT™
 
Stratacuity is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact us.
cclancy@stratacuity.com
Code: DiscDevt
 
 
 
 
 
 
 
 
EEO Employer
Apex Systems is an equal opportunity employer. We do not discriminate or allow discrimination on the basis of race, color, religion, creed, sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), age, sexual orientation, gender identity, national origin, ancestry, citizenship, genetic information, registered domestic partner status, marital status, disability, status as a crime victim, protected veteran status, political affiliation, union membership, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at 844-463-6178-6178.