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Senior or Principal Scientist - Liver Biology (Gene Therapy) in Cambridge, MA at APEX Systems

Date Posted: 1/12/2019

Job Snapshot

Job Description

Job #:  926069

Senior or Principal Scientist, Liver Biology (Gene Therapy), 926069

Job Scope & Purpose:

Our cutting edge biotech partner is expanding their biology team and seeking a Liver Biology Scientist to lead research projects hands-on and to contribute to the plans in building an AAV Liver Biology pipeline of therapies. You will be relied upon to contribute to the design of experiments in both in vitro and in vivo preclinical studies and work externally with CRO partners to progress critical studies. Core expertise in AAV (Adeno-associated virus) library mining is desired as you will be taking on gene therapy delivery issues as you develop the science for this new start-up. You will ideally have worked in or related Liver Biology genetic disorders (Alpha-1 Antitrypsin Deficiency)  to create therapies for patients in need. Their team is seeking a Scientist that is scientifically rigorous, highly organized, and significant attention to details.  This team comes with recent Series A investment, great academic leaders who are driving the science, and a top-notch executive team for you to take your talents to. Contact Chris Clancy and the Permanent R&D recruitment team to learn more.

Primary Job Responsibilities:

  • Ability to lead the development and implementation of a preclinical research plan from discovery to IND for AAV Gene Therapy Programs
  • Identify and propose projects to senior management for approval and then drive progress to the clinic
  • Devise in vitro disease models and develop new biomarker assays for incorporation into vivo models.
  • Mentor and lead teams of  Research Associates and direct the work of lab team for successful outcomes
  • Establish and Foster external partnerships with academic and industry collaborations
  • Assist in securing intellectual property, including detailed descriptions for patent filing and/or proof of concept work
  • Hands-on expertise in the characterization of cell models from hepatocytes lines, non-parenchymal cells, and primary cell lines to be used in drug discovery and development efforts.
  • Design, development, and characterization of advanced liver cell culture systems.

Primary J

Job Requirements

  •  PhD or equivalent with focus on Liver Disorders and Biology with a preference for 2+ years industry experience or a minimum of 4+ years of Postdoctoral academic laboratory experience will be considered
  • Proven ability to work independently and design experiments, trouble shoot, interpret and report data back to teams
  • Expert experience with cell and molecular biology assays including maintenance of mammalian cell cultures, growth and survival assays, immunoassays, si/shRNA techniques, RNA-seq 
  • Ability to design and execute medium and high-throughput cell based assays
  • Proven track record of leading research programs and teams towards pre-clinical studies 
  • High energy level, focus, a passion and sense of urgency for developing important new medicines for devastating diseases? and patients in need
  • Prior success discovering and developing successful novel gene therapy in drug discovery settings are ideal

About Stratacuity:

Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.

PROVEN SCIENTIFIC PLACEMENT™

Stratacuity is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact us at info@stratacuity.com  877-787-2821.

EEO Employer

Apex is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at 844-463-6178