Sr. / Research Associate - Hematology in Cambridge, MA at APEX Systems

Date Posted: 1/16/2020

Job Snapshot

  • Employee Type:
    Full-Time
  • Location:
    Cambridge, MA
  • Job Type:
  • Experience:
    Not Specified
  • Date Posted:
    1/16/2020

Job Description

Job #:  1017170
Research Associate/ Senior Research Associate, Hematology 1017170
 
Job Scope & Purpose:
Our Cambridge based client is seeking an experienced scientist to help us advance their hematology programs, including precision engineering of hematopoietic stem and progenitor cells for the treatment of rare blood cell disorders. The ideal candidate will support our in vitro and in vivo efforts developing next-generation base editing technologies and will be a self-motivated, technically competent research associate that is energized to join a small, fast-growing biotech.
Primary Job Responsibilities:
  • Primary/stem cell (human CD34+, iPSC) isolation/purification, culture and functional characterization.
  • Assist in designing, planning, and executing editing experiments with primary/stem cells (CD34+, iPSC).
  • Cellular staining and multicolor flow cytometry (analytic and sorting).
  • Design and clone expression vectors.
  • Design and run DNA/RNA purification and quantification assays (qPCR, ddPCR and RNA-seq).
  • Assist in the design, planning, and execution of in vivo engraftment studies.

Primary Job Requirements:
  • BA/BS in biological science or related discipline, MS is preferred.
  • Proven expertise in primary or stem cell culture [pluripotent stem cell or hematopoietic stem and progenitor cell (HSPC) experience a plus].
  • Experience in HSPC-relevant experimental techniques, including both in vitro cellular assays and in vivo transplant models is highly desirable.
  • Proficiency in molecular biology applications, including primer design, cloning (Gibson, USER, restriction), NGS sample preparation, DNA/RNA purification, and quantification methods such as qPCR, ddPCR or RNA-seq.
  • Good understanding of gene editing tools and principles (ZFN, TALEN, CRISPR, or DNA base editors). Previous experience in gene editing is preferable but not required.
  • Solid foundation in multi-color flow cytometry and cell sorting.
  • Experience with in vivo mouse models and/or willingness to learn is advantageous.
  • Familiar with DNA analysis software (e.g. Geneious, Vector NTI, Primer 3).
  • Proficient in the use of programs like MS Excel & PowerPoint and GraphPad Prism for data entry, analysis, visualization and presentation.
  • Attention to detail, critical data analysis capabilities, and strong problem-solving skills are required.

About Stratacuity:
 
Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.
PROVEN SCIENTIFIC PLACEMENT™
 
Stratacuity is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact us. 
kkerouac@stratacuity.com
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vbaker@stratacuity.com
Code: DiscDevt
 
 
 
 
 
 
 
 
EEO Employer
Apex Systems is an equal opportunity employer. We do not discriminate or allow discrimination on the basis of race, color, religion, creed, sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), age, sexual orientation, gender identity, national origin, ancestry, citizenship, genetic information, registered domestic partner status, marital status, disability, status as a crime victim, protected veteran status, political affiliation, union membership, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at 844-463-6178.